Metabolic Reprogramming by Oncogenic KSHV
Friday, March 27, 2020
USC-UPC DEN Building, Lecture Room C 163
925 W. 34th St., Los Angeles, CA 90089-0641
1 CE credit will be given.
Herpesviruses are ubiquitous pathogens and establish persistent infection in infected individuals. Though asymptomatic in immune-competent individuals, herpesvirus infection can be fatal in immune-compromised patients such as organ-transplant recipients and AIDS patients. Kaposi’s sarcoma is the leading neoplasm in AIDS patients and is caused by Kaposi’s sarcoma-associated herpesvirus (KSHV). As an intracellular obligate pathogen, KSHV relies on cellular biological machinery (e.g., metabolism) to propagate and persist in the host. Molecular details concerning how KSHV utilizes cellular metabolic pathways to achieve persistent infection and cause KSHV-associated malignancies are being discovered. This symposium will feature cutting-edge research on key cellular metabolic pathways and strategies by which KSHV modulates them during infection.
8:00 AM Registration Opens; Continental Breakfast Available
8:45 – 9:00 AM Welcome remarks by Dean Avishai Sadan, followed by Dr. Pinghui Feng
Introduction by organizers
9:00 – 9:40 AM Heather Christofk, UCLA - Metabolic Transitions in Cancer: Lessons from Viral Infection.
9:40 – 10:20 AM Caius Radu, UCLA - Reprogramming of Tumor Metabolism by Type I Interferon
10:20 – 10:35 AM Coffee break
10:35 – 11:15 AM Jae Jung, USC - Oncogenic Human Herpesvirus Hijacks Proline Metabolism for Tumorigenesis
11:15 – 11:55 AM Stacey Finley, USC - Multiscale Model Predicts Dynamics of Metabolic Reprogramming in Tumor Spheroids
11:55 – 12:35 AM Jun Zhao, USC - KSHV Hijacks CAD-mediated RelA Deamidation to Promote Glycolysis and Cell Proliferation
12:35 – 2:00 PM Lunch
2:00 – 2:40 PM Michael Lagunoff, University of Washington - Metabolic Requirements for KSHV Latency in Endothelial Cells
2:40 – 3:20 PM Shou-Jiang Gao, University of Pittsburgh - Metabolism and metabolic sensors in KSHV-induced cellular transformation
3:20 – 3:35 PM Coffee break
3:35 – 4:15 PM Michael McGrath, UCSF - The ACSR and its use in defining the HIV reservoir
4:15 – 4:55 PM Jamey Young, Vanderbilt - 13C Flux Analysis in Metabolism Research: From Cells to In Vivo Models
4:55 – 5:35 PM Nicholas Graham, USC - A Synthetic Lethal Drug Combination Mimics Glucose Deprivation-Induced Cancer Cell Death in the Presence of Glucose
5:35 – 5:45 PM Awards & Closing Remarks
6:30 PM Faculty dinner