Feng lab full pub list

* indicates Dr. Feng’s postdoctoral fellows and graduate students

PEER-REVIEWED RESEARCH ARTICLES

  1. Feng P, Everly DN Jr, Read GS. mRNA decay during herpesvirus infections: interaction between a putative viral nuclease and a cellular translation factor. J Virol. 2001 Nov;75(21):10272-80. PubMed PMID: 11581395; PubMed Central PMCID: PMC114601.
  2. Everly DN Jr, Feng P, Mian IS, Read GS. mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease. J Virol. 2002 Sep;76(17):8560-71. PubMed PMID: 12163576; PubMed Central PMCID: PMC136990.
  3. Feng P, Park J, Lee BS, Lee SH, Bram RJ, Jung JU. Kaposi’s sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J Virol. 2002 Nov;76(22):11491-504. PubMed PMID: 12388711; PubMed Central PMCID: PMC136794.
  4. Park J, Cho NH, Choi JK, Feng P, Choe J, Jung JU. Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts. J Virol. 2003 Aug;77(16):9041-51. PubMed PMID: 12885920; PubMed Central PMCID: PMC167239.
  5. Feng P, Scott CW, Cho NH, Nakamura H, Chung YH, Monteiro MJ, Jung JU. Kaposi’s sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation. Mol Cell Biol. 2004 May;24(9):3938-48. PubMed PMID: 15082787; PubMed Central PMCID: PMC387769.
  6. Chung YH, Cho NH, Garcia MI, Lee SH, Feng P, Jung JU. Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein. J Virol. 2004 Jun;78(12):6489-97. PubMed PMID: 15163742; PubMed Central PMCID: PMC416526.
  7. Lee SH, Chung YH, Cho NH, Gwack Y, Feng P, Jung JU. Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein. Mol Cell Biol. 2004 Jun;24(12):5369-82. PubMed PMID: 15169900; PubMed Central PMCID: PMC419894.
  8. Cho NH, Feng P, Lee SH, Lee BS, Liang X, Chang H, Jung JU. Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri. J Exp Med. 2004 Sep 6;200(5):681-7. Epub 2004 Aug 30. PubMed PMID: 15337788; PubMed Central PMCID: PMC2212737.
  9. Feng P, Everly DN Jr, Read GS. mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. J Virol. 2005 Aug;79(15):9651-64. PubMed PMID: 16014927; PubMed Central PMCID: PMC1181552.
  10. Lee BS, Lee SH, Feng P, Chang H, Cho NH, Jung JU. Characterization of the Kaposi’s sarcoma-associated herpesvirus K1 signalosome. J Virol. 2005 Oct;79(19):12173-84. PubMed PMID: 16160144; PubMed Central PMCID: PMC1211520.
  11. Shin, Y.C., Nakamura, H., Liang, X., Feng, P., Chang, H., Kowalik, T.F., Jung, J.U. (2006). Inhibition of the ATM/p53 signal transduction pathway by Kaposi’s sarcoma-associated herpesvirus interferon regulatory factor 1. J Virol. 2006 Mar;80(5):2257-66. PubMed PMID: 16474133; PubMed Central PMCID: PMC1395370.
  12. Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol. 2006 Jul;8(7):688-99. Epub 2006 Jun 25. PubMed PMID: 16799551.
  13. Feng P, Liang C, Shin YC, Xiaofei E, Zhang W, Gravel R, Wu TT, Sun R, Usherwood E, Jung JU. A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein. PLoS Pathog. 2007 Dec;3(12):e174. PubMed PMID: 18069888; PubMed Central PMCID: PMC2134948.
  14. Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 2008 Jul;10(7):776-87. doi: 10.1038/ncb1740. Epub 2008 Jun 15. PubMed PMID: 18552835; PubMed Central PMCID: PMC2878716.
  15. Feng H, Dong X, Negaard A, Feng P. Kaposi’s sarcoma-associated herpesvirus K7 induces viral G protein-coupled receptor degradation and reduces its tumorigenicity. PLoS Pathog. 2008 Sep 19;4(9):e1000157. doi: 10.1371/journal.ppat.1000157. PubMed PMID: 18802460; PubMed Central PMCID: PMC2529400
  16. Feng H, Sun Z, Farzan MR, Feng P. Sulfotyrosines of the Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor promote tumorigenesis through autocrine activation. J Virol. 2010 Apr;84(7):3351-61. doi: 10.1128/JVI.01939-09. Epub 2010 Jan 27. PubMed PMID: 20106924; PubMed Central PMCID: PMC2838108.
  17. Dong X, Feng H, Sun Q, Li H, Wu TT, Sun R, Tibbetts SA, Chen ZJ, Feng P. Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication. PLoS Pathog. 2010 Jul 29;6(7):e1001001. doi: 10.1371/journal.ppat.1001001. PubMed PMID: 20686657; PubMed Central PMCID: PMC2912392.
  18. Dong X, Feng P. Murine gamma herpesvirus 68 hijacks MAVS and IKKβ to abrogate NFκB activation and antiviral cytokine production. PLoS Pathog. 2011 Nov;7(11):e1002336. doi: 10.1371/journal.ppat.1002336. Epub 2011 Nov 10. PubMed PMID: 22110409; PubMed Central PMCID: PMC3213086.
  19. Dong X, Feng P. Dissecting host-virus interaction in lytic replication of a model herpesvirus. J Vis Exp. 2011 Oct 7;(56). pii: 3140. doi: 10.3791/3140. PubMed PMID: 22006158; PubMed Central PMCID: PMC3227218.
  20. Dong X, He Z, Durakoglugil D, Arneson L, Shen Y, Feng P. Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation. J Virol. 2012 Feb;86(4):1930-41. doi:10.1128/JVI.06127-11. Epub 2011 Nov 30. PubMed PMID: 22130545; PubMed Central PMCID: PMC3302405.
  21. Wang Y, Lu X, Zhu L, Shen Y, Chengedza S, Feng H, Wang L, Jung JU, Gutkind JS, Feng P. IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11139-44. doi:10.1073/pnas.1219829110. Epub 2013 Jun 14. Erratum in: Proc Natl Acad Sci U S A. 23;110(30):12498. Gutkind, Julio S [corrected to Gutkind, J Silvio]. PubMed PMID: 23771900; PubMed Central PMCID: PMC3703966.
  22. Liang Q, Chang B, Brulois KF, Castro K, Min CK, Rodgers MA, Shi M, Ge J, Feng P, Oh BH, Jung JU. Kaposi’s sarcoma-associated herpesvirus K7 modulates Rubiconmediated inhibition of autophagosome maturation. J Virol. 2013 Nov;87(22):12499-503. doi: 10.1128/JVI.01898-13. Epub 2013 Sep 11. PubMed PMID: 24027317; PubMed Central PMCID: PMC3807930.
  23. He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A*, Feng P, Deretic V, Pepperkok R, Tagaya M, Yoon HS, Liang C. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat Cell Biol. 2013 Oct;15(10):1206-19. doi: 10.1038/ncb2848. Epub 2013 Sep 22. PubMed PMID: 24056303; PubMed Central PMCID: PMC3805255.
  24. He Z, Zhao J, Zhang J, Jung JU, Feng P. NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi’s sarcoma-associated herpesvirus. J Virol. 2014 Jan;88(1):444-55. doi: 10.1128/JVI.01716-13. Epub 2013 Oct 23. PubMed PMID: 24155403; PubMed Central PMCID: PMC3911695.
  25. Lee HR, Doğanay S, Chung B, Toth Z, Brulois K, Lee S, Kanketayeva Z, Feng P, Ha T, Jung JU. Kaposi’s sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication. J Virol. 2014 Feb;88(4):2183-94. doi:10.1128/JVI.02106-13. Epub 2013 Dec 11. PubMed PMID: 24335298; PubMed Central PMCID: PMC3911525.
  26. Zhang J, Zhu L, Feng P. Dissecting innate immune signaling in viral evasion of cytokine production. J Vis Exp. 2014 Mar 2;(85). doi: 10.3791/51078. PubMed PMID: 24637875.
  27. Brulois K, Toth Z, Wong LY, Feng P, Gao SJ, Ensser A, Jung JU. Kaposi’s sarcomaassociated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication. J Virol. 2014 Aug;88(16):9335-49. doi: 10.1128/JVI.00873-14. Epub 2014 Jun 4. PubMed PMID: 24899205; PubMed Central PMCID: PMC4136276.
  28. He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. Mol Cell. 2015 Apr 2;58(1):134-46. doi: 10.1016/j.molcel.2015.01.036. Epub 2015 Mar 5. PubMed PMID: 25752576; PubMed Central PMCID: PMC4385502. Preview section by Daniel Kolakofsky and Dominique Garcin.
  29. Zhang J, He S, Wang Y, Brulois K, Lan K, Jung JU, Feng P. Herpesviral G proteincoupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase. PLoS Pathog. 2015 Mar 26;11(3):e1004768. doi: 10.1371/journal.ppat.1004768. eCollection 2015 Mar. PubMed PMID: 25811856; PubMed Central PMCID: PMC4374719.
  30. Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung JU. Identification of the Essential Role of Viral Bcl-2 for Kaposi’s Sarcoma- Associated Herpesvirus Lytic Replication. J Virol. 2015 May;89(10):5308-17. doi: 10.1128/JVI.00102-15. Epub 2015 Mar 4. PubMed PMID:25740994; PubMed Central PMCID: PMC4442505.
  31. Brulois K, Wong LY, Lee HR, Sivadas P, Ensser A, Feng P, Gao SJ, Toth Z, Jung JU. Association of Kaposi’s Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression. J Virol. 2015 Jun;89(11):6148-54. doi: 10.1128/JVI.00272-15. Epub 2015 Mar 25. PubMed PMID: 25810551; PubMed Central PMCID: PMC4442431.
  32. Zhang J, Zhu L, Lu X, Feldman ER, Keyes LR, Wang Y, Fan H, Feng H, Xia Z, Sun J, Jiang T, Gao SJ, Tibbetts SA, Feng P. Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice. PLoS Pathog. 2015 Jun 24;11(6):e1005001. doi: 10.1371/journal.ppat.1005001. eCollection 2015 Jun. PubMed PMID: 26107716; PubMed Central PMCID: PMC4479558.
  33. Xia Z, Guo M, Liu H, Jiang L, Li Q, Peng J, Li JD, Shan B, Feng P, Ma H. CBPdependent Wnt/β-catenin signaling is crucial in regulation of MDR1 transcription. Curr Cancer Drug Targets. 2015;15(6):519-32. PubMed PMID: 25968898.
  34. Minassian A*, Zhang J*, He S*, Zhao J*, Zandi E, Saito T, Liang C, Feng P. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul 29;11(7):e1005060. doi:10.1371/journal.ppat.1005060. eCollection 2015 Jul. PubMed PMID: 26221961; PubMed Central PMCID: PMC4519330.
  35. Yang Q, Tang S, Rang J, Zuo M, Ding X, Sun Y, Feng P, Xia L. Detection of toxin proteins from Bacillus thuringiensis strain 4.0718 by strategy of 2D-LC-MS/MS. Curr Microbiol. 2015 Apr;70(4):457-63. doi: 10.1007/s00284-014-0747-9. Epub 2014 Dec 5. PubMed PMID: 25477065.
  36. Seo GJ, Yang A, Tan B, Kim S, Liang Q, Choi Y, Yuan W, Feng P, Park HS, Jung JU. Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell Rep. 2015 Oct 13;13(2):440-9. doi: 10.1016/j.celrep.2015.09.007. Epub 2015 Oct 1. PubMed PMID: 26440888; PubMed Central PMCID: PMC4607670.
  37. Feldman ER, Kara M, Oko LM, Grau KR, Krueger BJ, Zhang J*, Feng P, van Dyk LF, Renne R, Tibbetts SA. A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency. mSphere. 2016 Apr;1(2). pii: e00105-15. Epub 2016 Mar 2. PMID: 27110595.
  38. Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan WM, Huang C, Akbari O, Tibbetts SA, and Feng P. IkB e kinase is an NFATc1 kinase that inhibits T cell immune responses. Cell Reports 2016 Jul 12;16(2):405-18. doi: 10.1016/j.celrep.2016.05.083.
  39. Zhu Y, Ramos da Silva S, He M, Liang Q, Lu C, Feng P, Jung JU, Gao SJ. An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS Pathog. 2016 May 17;12(5):e1005648. doi: 10.1371/journal.ppat. 1005648. eCollection 2016 May. PMID: 27187079.
  40. Zhao J, Zeng Y, Xu SM, Chen J, Shen G, Yu C, Peng J, Knipe DM, Yuan WM, Xu WQ, Zhang C, Xia Z, and Feng P. A viral deamidase targets RIG-I to block RNA-induced activation. Cell Host & Microbe. 2016 Nov 16. pii: S1931-3128(16)30437-1. doi: 10.1016/j.chom.2016.10.011. Preview section by Dominique Garcin.
  41. Liang Q, Wei D, Chung B, Brulois KF, Guo C, Dong S, Gao SJ, Feng P, Liang C, Jung JU. A novel role of vBcl2 in the virion assembly of Kaposi’s sarcoma-associated herpesvirus. J Virol. 2017 Nov 22. pii: JVI.00914-17. doi: 10.1128/JVI.00914-17. PMID: 29167347
  42. Lee HR, Li F, Choi UY, Yu HR, Aldrovandi GM, Feng P, Gao SJ, Hong YH, and Jung JU. KSHV vIRF3 deregulates HDAC5 activity to transform lymphatic endothelial cells. mBio (In press).
  43. Zhang J, Zhao J, Li J, Xu S, He S, Zeng Y, Xie L, Xie N, Liu T, Lee K, Seo G-J, Chen L, Stabell, A.C, Xia Z, Sawyer S.L, Jung JU, Huang C, and Feng P. Species-specific deamidation of cGAS facilitates herpes simplex virus 1 lytic replication. Cell Host & Microbe. 2018 Aug 8;24(2):234-248.e5. doi: 10.1016/j.chom.2018.07.004. See highlight in Science Signaling.
  44. Li J, Xu S, Zhao J, Xiao J, Zhang J, Tian M, Carriere J, Zeng Y, Lee Katie, Feng H, and Feng, P. Antiviral activity of a purine synthesis enzyme reveals a key role of protein deamidation in protein nuclear import (In press, Nature Microbiology).
  45. Qin C, Feng S, Feng P. STeerING PI4P for innate immune activation. Immunity. 2023. 14;56(3):463-465. PMID: 36921569
  46. Qin C, Rao Y, Yuan H, Wang T, Zhao J, Espinosa B, Liu Y, Zhang S, Savas AC, Liu Q, Zarinfar M, Rice S, Henley J, Comai L, Graham NA, Chen C, Zhang C and Feng P. SARS-CoV-2 Couples Evasion of Inflammatory Response to Activated Nucleotide Synthesis. PNAS. 2022. 119(26):e2122897119. PMID: 35700355

PEER-REVIEWED REVIEW ARTICLES

  1. Liang C, Feng P, Ku B, Oh BH, Jung JU. UVRAG: a new player in autophagy and tumor cell growth. Autophagy. 2007 Jan-Feb;3(1):69-71. Epub 2007 Jan 27. Review. PubMed PMID: 17106237.
  2. Feng, P. and Dong, X.N. (2010) Innate Immune Exploitation by a Model Herpesvirus. Front. Biol. 2010, 5(6): 473–477. DOI 10.1007/s11515-010-0920-x. Peer-reviewed Highlight.
  3. Feng P, Moses A, Früh K. Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses. Curr Opin Virol. 2013 Jun;3(3):285-95. doi: 10.1016/j.coviro.2013.05.011. Epub 2013 Jun 2. Review. PubMed PMID: 23735334; PubMed Central PMCID: PMC4397892.
  4. Zhao J, He S, Minassian A, Li J, Feng P. Recent advances on viral manipulation of NF- κB signaling pathway. Curr Opin Virol. 2015 Dec;15:103-11. doi: 10.1016/j.coviro.2015.08.013. Epub 2015 Sep 15. Review. PubMed PMID: 26385424; PubMed Central PMCID: PMC4688235.
  5. Zhao J, Li J, Xu S, Feng P. Emerging Roles of Protein Deamidation in Innate Immune Signaling. J Virol. 2016 Apr 14;90(9):4262-8. doi: 10.1128/JVI.01980-15. Print 2016 May 1. Review. PMID: 26889032 53.
  6. Zhang J, Feng H, Xu S, Feng P. Hijacking GPCRs by viral pathogens and tumor. Biochem Pharmacol. 2016 Apr 6. pii: S0006-2952(16)30002-8. doi: 10.1016/j.bcp.2016.03.021. [Epub ahead of print] Review. PMID: 27060663
  7. Zhang J, Tian M, Xia Z, Feng P. Roles of IκB kinase ε in the innate immune defense and beyond. Virol Sin. 2016 Dec;31(6):457-465. doi: 10.1007/s12250-016-3898-y. Review. PMID:28063014

BOOKS, MONOGRAPHS, AND TEXT BOOKS

Feng, P., Scott, C., Lee, S.-H., Cho, N.-H., and Jung, J.U. (2004). Manipulation of apoptosis by herpes viruses (Kaposi’s Sarcoma Pathogenesis). Chapter 11, In progress in molecular and subcellular biology. p. 191-205. Springer-Verlag Press, Heidelberg, Germany.

MEDIA AND TELEVISION APPEARANCES

Media interview by LA Times, 26 March 2013